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The size and migration of fibroblasts are increased after Trimethylamine N-oxide (TMAO) treatment compared with non-treated fibroblasts in vitro
Med Lett Drugs Ther
In primary cultures of rat cerebral cortex neurons
4-d]pyrimidin-6-amine
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LY3009120 Catalog No.:M8369-2 The size and migration ofLY3009120, also known as DP 4978, is potent and selective pan RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in
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