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2013 Jun 7
and also carries the US NCI designation NSC-707389
Smiles: O=C1C=C(N=C2C3=CC=CC=C3C=CN21)N1CCOCC1
128(4):574-83
30)/t24-/m0/s1
PND-1186 Catalog No.:M9572-2 2013 Jun 7PND 1186, also known as SR 2156 and VS 4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1. 5 nM in vitro. PND 1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1. 0 M PND 1186 (>5 fold above IC50) had limited effects on cell proliferation. However, under non adherent conditions as spheroids and as colonies in soft agar, 0. 1 M PND 1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase 3
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