Gliotoxin Size:10mg solid 4-dichloro-N-(pentan-2-yl)benzamide

4-dichloro-N-(pentan-2-yl)benzamide

TAME at concentration of 200 μM dramaticly inhibits the ubiquitin ligase activity of the Anaphase-Promoting Complex (APC)

InChi: InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6

hydrochloride (1:1)

Zerit sodium

Gliotoxin Size:10mg solid 4-dichloro-N-(pentan-2-yl)benzamideGliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells. Gliotoxin inhibits inducible NF B activity by preventing IB degradation, which consequently induces host cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus