PXS-5153A monohydrochloride 5041 O=C1NCCC2NC(=CC=21)C1C=CN=CC=1

O=C1NCCC2NC(=CC=21)C1C=CN=CC=1

cell death

4 for AR wild type and AR mutation T877A

T0901317 (10-40 μM

It was developed by Boehringer Ingelheim and Eli Lilly and Company

PXS-5153A monohydrochloride 5041 O=C1NCCC2NC(=CC=21)C1C=CN=CC=1PXS 5153A monohydrochloride is a potent, selective, orally active and fast acting lysyl oxidase like 2 3 enzymatic (LOXL2 LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS 5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis. Product information Molecular Weight: 438. 95 Formula: C20H24ClFN4O2S Chemical Name: 3 {1 [(2Z) 4 amino 2 fluorobut 2 en 1 yl] 2 methyl