CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 0187 Smiles: O=C(COC1C=CC(Cl)=CC=1)N[C@@H]1CC[C@H](CC1)NC(=O)COC1C=CC(Cl)=CC=1

Smiles: O=C(COC1C=CC(Cl)=CC=1)N[C@@H]1CC[C@H](CC1)NC(=O)COC1C=CC(Cl)=CC=1

000-fold selectivity against all PI3K isoforms (α

8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3

Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin

InChiKey: FKSFKBQGSFSOSM-QFIPXVFZSA-N

CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 0187 Smiles: O=C(COC1C=CC(Cl)=CC=1)N[C@@H]1CC[C@H](CC1)NC(=O)COC1C=CC(Cl)=CC=1CB 5083, CAS No. 1542705 92 9, is a novel first in class, potent orally bio available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti tumor activity in solid and hematological models . CB 5083 causes rapid and sustained accumulation of poly ubiquitin in tumor xenografts after a single administration. CB 5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB 5083 appears to