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is a potential PKD binding agent
InChiKey: NYHXPFHFIMRKDS-UHFFFAOYSA-N
cis-22a displays antiproliferative effects on T47D human breast cancer cells
67469-81-2
1371/journal
AZD-5438 702 is a potential PKD bindingAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.
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