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Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo
CAS Number: 1245537-68-1
1186/s12974-015-0286-8
J Nat Sci Biol Med
CAS Number: 486-35-1
PF-04995274 0270 Small molecule chloropyramine hydrochloride (C4)PF 04995274 (PF 4995274) is a potent, high affinity, orally active and partial agonist of serotonin 4 receptor (5 HT4R) with EC50 of 0. 47 nM, 0. 36 nM, 0. 37 nM and 0. 26 nM for human 5 HT4A 4B 4D 4E, respectively. As for rat 5 HT4S 4L 4E, the EC50 is 0. 59 nM, 0. 65 nM and 0. 62 nM, respectively. PF 04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. Product information CAS Number: 1331782 27 4
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