DOXO-EMCH - CAS# 151038-96-9 Size:Solid 10 mg 4-tetrahydroisoquinoline-6-sulfonamide hydrochloride

4-tetrahydroisoquinoline-6-sulfonamide hydrochloride

and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells

Formula: C27H45N5O5

CN1CCC(CC1)=C1C2=CC=CC=C2C=CC2=CC=CC=C21

Formula: C21H22ClN3O

DOXO-EMCH - CAS# 151038-96-9 Size:Solid 10 mg 4-tetrahydroisoquinoline-6-sulfonamide hydrochlorideAldoxorubicin, also known as INNO 206 and Doxo EMCH, is the 6 maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO 206 binds selectively to the cysteine 34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly,