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InChiKey: HXPQWNPLNIEJOW-UHFFFAOYSA-N
Smiles: NC1=CC2=C(NCCC3C=CC(=CC=3)OC3C=CC=CC=3)N=CN=C2C=C1
Smiles: CC1NC(/C=C2/C3=CC(=CC=C3NC/2=O)S(=O)(=O)CC2C(Cl)=CC=CC=2Cl)=C(C)C=1C(=O)N1CCC[C@@H]1CN1CCCC1
InChi: InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12
Chemical Name: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol hydrochloride
GDC-0032 Size:Solid 2 mg InChiKey: HXPQWNPLNIEJOW-UHFFFAOYSA-NTaselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0. 2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC 0032 preferentially inhibited PIK3CA
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