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AWD 131-138 - CAS# 188116-07-6 Catalog No.:M10321-2 and biological evaluation of an

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Description

and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes

Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA

It prevents palmitylation of Wnt proteins by Porcupine (a membrane-bound O-acyltransferase)

Smiles: OC(=O)C1C=CC(=CC=1)NC1=NC2=C(CN=C(C3C(F)=CC=CC=3F)C3=CC(Cl)=CC=C32)C=N1

1401–1412

AWD 131-138 - CAS# 188116-07-6 Catalog No.:M10321-2 and biological evaluation of anImepitoin, also known as AWD 131 138, a novel antiepileptic drug for the treatment of canine idiopathic epilepsy. Imepitoin is a centrally acting anti epileptic which crosses the blood brain barrier. It inhibits seizures via potentiation of the GABA a receptor mediated inhibitory effects on the neurones. It also has weak calcium channel blocking effect which may contribute to its anticonvulsive properties. Product information CAS Number: 188116 07 6

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