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VHL Ligand-Linker Conjugates 15 can be used to design PROTACs
203(2):135-41
7 days) shows a > 75% reduction on Aβ40 and Aβ42 in CSF after dosing and returns slowly to baseline over the next 7 days
1-5H3/b10-6+
InChi: InChI=1S/C19H16BrNO2/c20-15-9-18-17(22-10-23-18)8-14(15)19-13-6-3-5-11(13)12-4-1-2-7-16(12)21-19/h1-5
Azido-PEG8-hydrazide Catalog No.:M26818-C VHL Ligand-Linker Conjugates 15 canAzido PEG8 hydrazide is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 2353410 11 2 Molecular Weight: 481. 54 Formula: C19H39N5O9 Chemical Name: 1 azido 3,6,9,12,15,18,21,24 octaoxaheptacosane 27 hydrazide Smiles: [N ]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NN InChiKey: XSHZSHNFUKYUOV UHFFFAOYSA N InChi: InChI=1S C19H39N5O9 c20 23 19(25)1 3 26 5 7 28 9 11 30 13 15 32 17 18 33 16 14 31 12 10 29 8 6
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