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Pedranzini L
and has slight activity against HDAC8 (IC50 ~0
Embryos treated with SJ000291942 display the most severe ventralization and SJ000291942 is also the most potent
but has no effect on YM cells
The inhibition of growth of human tumor xenografts in mice
SC-26196 - CAS# 218136-59-5 0060 Pedranzini LSC 26196, CAS No. 218136 59 5, is a D6D inhibitor (IC50 = 0. 2 M in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). SC 26196 inhibited the desaturation of 2 microM [1 14C] 18: 2n 6 by 87 95% in cultured human skin fibroblasts, coronary artery smooth muscle cells, and astrocytes. By contrast, SC 26196 did not affect the conversion of [1 14C]20: 3n 6 to 20: 4 in the fibroblasts,
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