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BLU-9931 inhibits proliferation of HCC cell lines that express an intact FGFR4 signaling complex
(2014) AACR San Diego
Canertinib has been reported as a substrate for OATP1B3
8 nM in mouse and rat chemotaxis assays
body weight
BO-264 - CAS# 2408648-20-2 Catalog No.:M7012-2 BLU-9931 inhibits proliferation of HCCBO 264, CAS No. 2408648 20 2, is a highly potent and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1. 5 nM. BO 264 demonstrated superior anti proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC) dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against
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