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InChiKey: VKLJPGAHSLIQKH-UHFFFAOYSA-N
FGF401 binds to and inhibits the activity of FGFR4
RO-5006036
Potent activity of carfilzomib
1999398A3P
PF-8380 03-204 InChiKey: VKLJPGAHSLIQKH-UHFFFAOYSA-NPF 8380 is a potent autotaxin inhibitor with an IC(50) of 2. 8 nM in isolated enzyme assay and 101 nM in human whole blood. PF 8380 has adequate oral bioavailability and exposures required for in vivo testing of autotaxin inhibition. Autotaxin's role in producing LPA in plasma and at the site of inflammation was tested in a rat air pouch model. The specific inhibitor PF 8380 , dosed orally at 30 mg kg, provided >95% reduction in both plasma and air
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