UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S MI-2 was nontoxic to mice

MI-2 was nontoxic to mice

Ciraparantag

GSK-J4 was used at 30 µM final concentration in cellular assays

Su-11274 exhibits a selective inhibition pattern toward different receptor mutated variants

PubMed PMID: 10762053

UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S MI-2 was nontoxic to miceUF 010, CAS No. 537672 41 6, is a Class I HDAC inhibitor (IC50 values are 0. 06, 0. 1, 0. 5 and 1. 5 M for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological