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SB 224289 is a potent antagonist with an ED50 of 3
Overexpression of p21-activated protein kinase 1 (PAK1) is frequently observed in HCC and is associated with a more aggressive tumor behavior
and as an adjunctive treatment for depression
InChi: InChI=1S/C18H18N2O4/c1-8(2)7-20-12(22)6-10(4)14-16(20)18(24)15-13(17(14)23)9(3)5-11(21)19-15/h5-6
[O-]C(=O)CC1=CC=CC=C1NC1C(Cl)=CC=CC=1Cl
AZ 12080282 dihydrochloride 2653 SB 224289 is a potentAZ 12080282 dihydrochloride is a selective inhibitor of Hh with IC50 value <0. 012 M . It is also reported that AZ 12080282 also has a selective inhibition to p38 with low nanomolar potency . Hedgehog (Hh) signaling plays an important role in a wide variety of developmental processes, including larval body segment development and adult appendages formation. Abnormal activation of Hh pathway may lead to developmental disease by transforming adult stem
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