Pexidartinib G4-Amine DGAT1-IN-3 blocks the human ether-a-go-go-related

DGAT1-IN-3 blocks the human ether-a-go-go-related gene (hERG) encoded potassium channel with an IC20 of 0

CAS Number: 212844-53-6

Smiles: CC1(C)[C@@H]2C[C@H](O)C3=C(C(=O)C[C@]4(C)[C@H](C[C@H](O)[C@]43C)[C@H](C)CC(=O)C[C@@H](C)C(O)=O)[C@@]2(C)CCC1=O

Proteinase-activated receptors (PARs) are a family of G protein-coupled receptors activated by the proteolytic cleavage of their N-terminal extracellular domain

Formula: C25H23Cl2N7O4

Pexidartinib G4-Amine DGAT1-IN-3 blocks the human ether-a-go-go-relatedPexidartinib (PLX 3397) is a potent, orally active, selective, and ATP competitive colony stimulating factor 1 receptor (CSF1R or M CSFR) and c Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX 3397) exhibits 10 to 100 fold selectivity for c Kit and CSF1R over other related kinases. Pexidartinib (PLX 3397) induces cell apoptosis and has anti tumor activity. Product information CAS Number: 1029044 16 3 Molecular Weight: 417. 81