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Formula: C17H18F3N3O3
is analog of Kobe0065
2ClH/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20
Smiles: COC1=CC=CC=C1C1=CC(NC2=CC(CS(N)(=O)=O)=CC=C2)=NC=N1
24)34-20/h6
PRX-08066 - CAS# 866206-54-4 411575 (isomer 3) Formula: C17H18F3N3O3PRX 08066 is a a novel 5 hydroxytryptamine receptor 2B antagonist, reduces monocrotaline induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5 HT(2B) expressing SI NET cell line, KRJ I, PRX 08066 inhibited proliferation (IC(50) 4. 6 x 10( 9)M) and 5 HT secretion (6. 9 x 10( 9)M) and decreased ERK1 2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1],
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