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Smiles: COC1=CC2=C(NC3=CC(O)=CC=C3)N=CN=C2C=C1OC
mean tumor numbers
It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM)
(2015) Chem Biol
Pignatti F
Su-11274 - CAS# 658084-23-2 Catalog No.:M6418-10 Smiles: COC1=CC2=C(NC3=CC(O)=CC=C3)N=CN=C2C=C1OCSu 11274, CAS No. 658084 23 2, is a selective Met tyrosine kinase inhibitor with IC50 of 10 nM. Su 11274 increases tumorigenicity and enriched for melanoma initiating cells by bioenergetic modulation. Su 11274 suppresses proliferation and motility of pancreatic cancer cells. Su 11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Su 11274 exhibits a selective inhibition pattern toward different receptor mutated