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and protein-protein interactions at 1 day after CFA administration
CPI-455 mediated KDM5 inhibition
2007 Jan 15
0b013e318164e762
(2004) J Pharmacol Exp Ther
E-7449 - CAS# 1140964-99-3 0290 and protein-protein interactions at 1E 7449, also known as 2X 121, CAS No. 1140964 99 3, is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E 7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes
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