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YQ128 (20 µM
PubMed PMID: 31735287
CP-724714 potently reduces the EGF-induced autophosphorylation of the chimera containing the erbB2 kinase domain at a concentration as low as 50 nmol/L (IC50=32 nM) but is markedly less potent against EGFR
Currently AZD6244 is undergoing Phase II/III clinical trials to treat solid tumors
transformation
EGFR/ErbB-2/ErbB-4 inhibitor-2 Catalog No.:M14718-2 YQ128 (20 µMEGFR ErbB 2 ErbB 4 inhibitor 2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0. 017 M, 0. 08 M, 1. 91 M. Product information CAS Number: 179248 61 4 Molecular Weight: 387. 43 Formula: C23H21N3O3 Chemical Name: N [4 (benzyloxy)phenyl] 6,7 dimethoxyquinazolin 4 amine Smiles: COC1=CC2=NC=NC(NC3C=CC(=CC=3)OCC3C=CC=CC=3)=C2C=C1OC InChiKey: DNOKYISWMVFYFA UHFFFAOYSA N InChi: InChI=1S C23H21N3O3 c1 27 21 12 19 20(13 22(21)28 2)24 15 25 23(19)26 17