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the activity of CZ415 against the human cardiac ion channel hERG is assessed in a whole-cell patch-clamp assay in HEK293 cells resulting in an IC50 of 48 μM
which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]
In vivo: In healthy young men and women volunteers
12)78)59(77)79-49(39(10)18-2)58(76)66(15)48(37(7)8)53(71)62-43(33-40-26-21-19-22-27-40)54(72)64(13)45(34-41-28-23-20-24-29-41)56(74)68-31-25-30-44(68)51(69)63-46/h19-24
VAL-083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells
TC OT 39 Catalog No.:M23225-C the activity of CZ415 againstProduct information CAS Number: 479232 57 0 Molecular Weight: 600. 78 Formula: C32H40N8O2S Chemical Name: (Z,2S) 2 (4 methyl 1,4 diazepane 1 carbothioyl) N [(2 methyl 4 {4 methyl 2,4,5,9 tetraazatricyclo[8. 4. 0. 0,]tetradeca 1(14),3(7),5,10,12 pentaene 9 carbonyl}phenyl)methyl]pyrrolidine 1 carboximidic acid Smiles: CC1=CC(=CC=C1C N=C(\O) N1CCC[C@H]1C(=S)N1CCCN(C)CC1)C(=O)N1CC2C=NN(C)C=2NC2=CC=CC=C12 InChiKey: KSNHHKZYKYNBEI NDEPHWFRSA N InChi:
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