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also has less inhibition on AChE/BChE with Ki of 48
Tripathy D
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains
InChiKey: FCNQMDSJHADDFT-WNSKOXEYSA-N
conscious rats
Thalidomide paverine hydrochloride also has less inhibition onThalidomide is a synthetic derivative of glutamic acid (alpha phthalimido glutarimide) with teratogenic, immunomodulatory, anti inflammatory and anti angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In
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