SCH772984 cin AZ3451 attenuates chondrocytes apoptosis by

AZ3451 attenuates chondrocytes apoptosis by activating autophagy in vitro

NC1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1

(2014) ChemMedChem

Formula: C19H19N3O3

but reduces open probability by > 90% with Ki=0

SCH772984 cin AZ3451 attenuates chondrocytes apoptosis bySCH772984 is an potent and selective ERK inhibitor with potential anticancer activity. SCH722984 showed activity against BRAF mutant, NRAS mutant and wild type melanoma. Combining vemurafenib and SCH722984 in BRAF mutant melanoma was synergistic in a majority of cell lines and significantly delayed the onset of acquired resistance in long term in vitro assays. Therefore, SCH772984 may be clinically applicable as a treatment for non BRAF mutant