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especially in a tumor microenvironment
2015 Jan 3
both β-catenin and panRas protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220
This dosing strategy is well tolerated
Epub 2013 Jul 19
CVT-10216 - CAS# 1005334-57-5 Catalog No.:M6674-2 especially in a tumor microenvironmentCVT 10216, CAS No. 1005334 57 5, is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT 10216 increases acetaldehyde after alcohol gavage and inhibits 2 bottle choice alcohol intake in heavy drinking rodents, including deprivation induced drinking. Moreover, CVT 10216 also prevents operant self administration and eliminates cue induced reinstatement of
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