PROTAC BRD4 Degrader-14 cinimide sodium 3)4)15-19(26)16-27-22-7-5-6-21-20(22)12-13-24-21/h5-13

3)4)15-19(26)16-27-22-7-5-6-21-20(22)12-13-24-21/h5-13

InChi: InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8

Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders

Chemical Name: 5-{2-ethoxy-5-[(2

34(3):634-8

PROTAC BRD4 Degrader-14 cinimide sodium 3)4)15-19(26)16-27-22-7-5-6-21-20(22)12-13-24-21/h5-13PROTAC BRD4 Degrader 14 is a PROTAC connected by ligands for von Hippel Lindau and BRD4, with IC50s of 1. 8 nM and 1. 7 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader 14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells. Product information Molecular Weight: 1150. 27 Formula: C57H61F2N9O11S2 Chemical Name: 8 (3,5 difluoropyridin 2 yl) N (2 {3 hydroxy 5 [2 ({[(2S) 1 [(2S,4R) 4 hydroxy 2 ({[4 (4 methyl 1,3