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10(7):e0132004
Chambers SK
Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis
129:453-461
It inhibits histone demethylase JMJD3
Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 size:10mg solid 10(7):e0132004Wnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while
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