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Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively
VRT 752271
(2002) Proc Natl Acad Sci U S A
14(3):1236-43
Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad
GSK-2981278 - CAS# 1474110-21-8 Catalog No.:M6485-10 Apoptosis Activator 2 is aGSK 2981278, CAS No. 1474110 21 8, is a highly potent and selective inverse agonist of retinoic acid receptor related orphan receptor gamma (ROR gamma). GSK 2981278 is a strong ROR selective inverse agonist that inhibits activation of the il17 promoter. GSK 2981278 robustly inhibits ROR mediated cytokine production at both the mRNA and protein level. GSK 2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK 2981278
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