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PF-4136309 inhibits hERG potassium current with an IC50 of 20 μM
5-dihydro-1H-pyrazole-3-carboxamide
InChiKey: XJDKPLZUXCIMIS-HMMYKYKNSA-N
THZ1 is a novel potent
Formula: C31H34F2N6O2
Angiotensin II human Catalog No.:M9539-10 PF-4136309 inhibits hERG potassium currentAngiotensin II is an endogenous potent vasoconstrictor peptide. The amino acid sequence of angiotensin II is Asp Arg Val Tyr Ile His Pro Phe His Leu. Angiotensin II increases blood pressure by stimulating the Gq protein in vascular smooth muscle cells (which in turn activates an IP3 dependent mechanism leading to a rise in intracellular calcium levels and ultimately causing contraction). In addition, angiotensin II acts at the Na H exchanger in the
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