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InChiKey: DZKIUEHLEXLYKM-UHFFFAOYSA-N
very good solubility
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2
Heteroaryl butanoic acid derivatives as leukotriene A4 hydrolase inhibitors and their preparation
EPZ-5676 was used at 1 µM final concentration in vitro and in cellular assays
Darusentan 9424) InChiKey: DZKIUEHLEXLYKM-UHFFFAOYSA-NDarusentan (Lu 135252) is a selective endothelin receptor A (ET A) receptor antagonist, which binds with a Ki of 1. 4 nM to the ET A receptor and a Ki of 184 nM to ET B receptor, respectively with a 100 fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single site kinetics, exhibiting a Ki of 13 nM. Product information CAS
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