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Smiles: CC1C=C(C=C(C)C=1CC1=CC=C(O)C(=C1)C(C)C)OCP(O)(O)=O
Targeting BET Bromodomains
PubMed PMID: 26448264
2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA)
Dorniak PL
LB-100 Catalog No.:M8527-10 Smiles: CC1C=C(C=C(C)C=1CC1=CC=C(O)C(=C1)C(C)C)OCP(O)(O)=OLB 100 is a protein phosphatase 2A(PP2A)inhibitor. LB 100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. LB 100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments. LB 100 dramatically increased intracellular p Smad3 level, which was responsible for the effect of LB 100 as a sensitizer. LB 100 downregulated Bcl 2 expression and enhanced sorafenib