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VER155008 also decreases amyloid plaques and PHF-tau associated with amyloid plaques in 5XFAD mice
InChi: InChI=1S/C58H70F3N9O9/c1-39(62-2)53(71)68-51(42-18-10-5-11-19-42)57(75)70-29-13-22-48(70)55(73)69-52(50(40-14-6-3-7-15-40)41-16-8-4-9-17-41)56(74)64-28-31-77-33-35-78-34-32-76-30-27-63-54(72)44-21-12-20-43(36-44)47-37-49(66-38-65-47)67-45-23-25-46(26-24-45)79-58(59
respectively) and is inactive against a general panel of over 200 kinases when tested at 10 µM
Smiles: COC1=CC=CC=C1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C
A phase I study of tasisulam sodium (LY573636 sodium)
YO-01027 I-IN-1 VER155008 also decreases amyloid plaquesYO 01027 (Dibenzazepine; DBZ) is a potent secretase inhibitor with IC50 values of 2. 92 and 2. 64 nM for Notch and APPL cleavage, respectively. Product information CAS Number: 209984 56 5 Molecular Weight: 463. 48 Formula: C26H23F2N3O3 Chemical Name: (2S) 2 [2 (3, 5 difluorophenyl)acetamido] N [(10S) 8 methyl 9 oxo 8 azatricyclo[9. 4. 0. 0, ]pentadeca 1(15), 2, 4, 6, 11, 13 hexaen 10 yl]propanamide Smiles:
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