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CFI-402257 increases aneuploidy in HCT116 cells when used at concentrations greater than 100 nM
The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM
Formula: C14H14O5S
InChi: InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7
Letrozole - CAS# 112809-51-5 Size:Solid 10 mg CFI-402257 increases aneuploidy in HCT116Letrozole, also known as CGS 20267, is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen dependent breast cancer cells. Aromatase, a cytochrome P 450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary,
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