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5-10 mg/Kg once per day
is a PEG derivative containing an azide group and an NHS ester
AGI-5198 has good cellular activities in TS603 glioma cell line
PSC-833 fully reverses resistance to crenolanib in both HL60/VCR and K562/ABCB1 cells
23(3):274-6
OTX015 - BET Inhibitor. CAS# 202590-98-5 size:2 mg solid 5-10 mg/Kg once per dayOTX015, CAS No. 202590 98 5, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10 19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down regulation of c MYC expression, and show the synergistic anti proliferative effects in combination with ALK inhibitors in ALKpos