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including p53 mutant cell lines
Formula: C29H29ClF3N7OS
171(2):273-285
The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression
OCCN1CCN(CCC=C2C3=CC=CC=C3SC3=CC=C(C=C32)C(F)(F)F)CC1
HQ-415 Catalog No.:M25075-C including p53 mutant cell linesHQ 415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ 415 is 15 M. IC50 value: 15 M (EC50)in vitro: In TDP 43 expressing cells, CQ fails to synergize with HQ 161 and actually antagonizes HQ 161 rescuing activity. In contrast, despite the fact that CQ was completely inactive against TDP 43, it strongly synergized with HQ 415, decreasing the EC50 from 16 to 5 M. HQ