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BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML
6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3
Chemical Name: N-(4-butylphenyl)-4-fluorobenzene-1-sulfonamide
2-dihydropyridine-3-amido}benzoic acid
by β- and γ-secretases
AP-18 Size:Contact [email protected] for quotation BGG463 potently inhibits T315I BCR–ABLAP 18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 M Cinnamaldehyde with an IC50 of 3. 1 M and 4. 5 M for human and mouse TRPA1, respectively. AP 18 reverses complete Freund's adjuvant (CFA) induced mechanical hyperalgesia in mice. AP 18 attenuated 30 M AITC induced Yo Pro uptake in a concentration dependent manner, with an IC50 of 10. 3 M. Product information CAS Number: 55224 94 7 Molecular Weight: 209. 67 Formula:
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