Exatecan Mesylate - CAS# 169869-90-3 0271 ((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

MLN8237 is currently in Phase II study for treatment of patients with ovarian

Smiles: [O-][N+](=O)C1=CC(Cl)=CC=C1S(=O)(=O)C1C=CC=CC=1

and suppressed tumor growth in vivo with a concomitant reduction in vessel formation

InChiKey: VUNOFAIHSALQQH-UHFFFAOYSA-N

Exatecan Mesylate - CAS# 169869-90-3 0271 ((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanoneExatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater