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InChi: InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H
It inhibits LSD1 in biochemical assay with an IC50 ~16 nM
Formula: C11H10N4O
the compounds induced p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases
Formula: C25H23Cl2N7O4
GSK-LSD1 - LSD1 Inhibitor. CAS# 2102933-95-7 0073 InChi: InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10HGSK LSD1, CAS No. 2102933 95 7, is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i. e. LSD2, MAO A, MAO B). GSK LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Product
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