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The metabolic activity of CMA07 and CMT-U27 cell lines is significantly decreased with 305 μM Oseltamivir phosphate treatment (p=0
Oral delivery of SSR128129E (30 mg/kg/day
Zimybase nitrate
Arch Otolaryngol Head Neck Surg
11)12)20-18-35(16-14-33)23-27(39)43-31(7
Folic acid Size:Solid 2 mg The metabolic activity of CMA07ABT 100 is an orally bioavailable farnesyltransferase inhibitor. ABT 100 inhibited proliferation of cells in vitro carrying oncogenic H Ras (EJ 1 bladder; IC(50) 2. 2 nmol L), Ki Ras (DLD 1 colon, MDA MB 231 breast, HCT 116 colon, and MiaPaCa 2 pancreatic; IC(50) range, 3. 8 9. 2 nmol L), and wild type Ras (PC 3 and DU 145; IC(50), 70 and 818 nmol L, respectively) as well as clonogenic potential. ABT 100 shows 70% to 80% oral bioavailability in mice.
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