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Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia
PubMed PMID: 25088224
and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo
DONOVANI intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC(50) value of 70 nM
InChi: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8
Crizotinib Hydrochloride - CAS# 1415560-69-8 Size:Solid 2 mg Aminopeptidase inhibition by the novelCrizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8
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