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ABT-888 dihydrochloride (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells
929007-72-7
9 nM in KYSE70 and A549 cells
which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs
Chemical Name: (E)-2-(4-carbamimidoyl-2
BMS-345541 hydrochloride Size:Solid 2 mg ABT-888 dihydrochloride (10 μM) suppressesBMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0. 3 and 4. 0 M for IKK and IKK respectively). It attenuates LPS induced cytokine production in vitro and blocks NFB dependent transcription in mice. BMS 345541 also suppresses joint destruction in a mouse model of arthritis. Product information CAS Number: 547757 23 3 Molecular Weight: 291. 78 Formula: C14H18ClN5 Synonym: BMS345541 hydrochloride BMS 345541 hydrochloride BMS 345541