TAK-448 Catalog No.:M30275-C Simufilam dose-dependently reduces Ab42-induced FLNA

Simufilam dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus

CAS Number: 2413-38-9

3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl)-3

8)/t2-/m0/s1

RVD-Hpα also high affinity CB2 positive allosteric modulator (Ki=50 nM)

TAK-448 Catalog No.:M30275-C Simufilam dose-dependently reduces Ab42-induced FLNATAK 448 (MVT 602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM. Product information CAS Number: 1234319 68 6 Molecular Weight: 1225. 35 Formula: C58H80N16O14 Chemical Name: N {1 [(1 {[({1 [(1 {[1 carbamoyl 2 (1H indol 3 yl)ethyl]carbamoyl} 4 (N'' methylcarbamimidamido)butyl)carbamoyl] 3 methylbutyl}carbamoyl)amino]carbamoyl} 2 phenylethyl)carbamoyl] 2 hydroxypropyl} 2 ({1 [2 acetamido 3 (4 hydroxyphenyl)propanoyl] 4