TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 CAS Number: 320-67-2

CAS Number: 320-67-2

LDN-214117 demonstrates selective inhibition of ALK2 and ALK1 in preference to ALK3 kinase activity

NLG919 was used at 10 µM final concentration in various in vitro assays

59(12):3099-107

in complex with the cytosolic protein FK-binding protein 12 (FKBP12)

TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 CAS Number: 320-67-2TAK 243 (MLN7243), CAS No. 1450833 55 2, is a potent, selective and cell permeable small molecule inhibitor of the ubiquitin activating enzyme (UAE) at nM range. The ubiquitin activating enzymes, found more active in cancer cells than in normal healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via proteasome. TAK 243 treatment caused depletion of cellular ubiquitin conjugates, resulting in