SSR128129E (free acid) - CAS# 848463-13-8 Catalog No.:M9736-2 4 mg/kg MK-8776 S-isomer is

4 mg/kg MK-8776 S-isomer is sufficient to induce the γ-H2AX biomarker while 8 mg/kg leads to enhanced tumor pharmacodynamic and regression responses relative to gemcitabine or MK-8776 S-isomer alone

2 and 2 μg/mL

Smiles: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@H]2[C@@H](CO)O[C@H](OC[C@H]3O[C@@H]4O[C@@H]5[C@@H](CO)O[C@H](O[C@@H]6[C@@H](CO)O[C@H](O[C@@H]7[C@@H](CO)OC(O[C@@H]8[C@@H](CO)O[C@H](O[C@@H]9[C@@H](CO)O[C@H](O[C@@H]%10[C@@H](CO)O[C@H](O[C@H]3[C@H](O)[C@H]4O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]2O)[C@@H]1O

TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains

2015 Jan 27

SSR128129E (free acid) - CAS# 848463-13-8 Catalog No.:M9736-2 4 mg/kg MK-8776 S-isomer isSSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. Product information CAS Number: 848463 13 8 Molecular Weight: 324. 33 Formula: C18H16N2O4 Synonym: SSR free acid SSR 128129E free acid Chemical Name: 2 amino 5 (1 methoxy 2 methylindolizine 3 carbonyl)benzoic acid Smiles: