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CN1C=C(C2=C(C3=C4CC(CN)CCN4C4=CC=CC=C34)C(=O)NC2=O)C2=CC=CC=C12
CPI203 could be dosed to the mice by oral administration at 5 mg/kg twice per day for 7 days
SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages
Smiles: C[C@@H]1COCCN1C1=CC(=NC(=N1)C1C=CC=C2NC=CC=12)C1(CC1)S(C)(=O)=O
LKB1-activated NUAK1 kinase
ABC294640 - CAS# 915385-81-8 Catalog No.:M6465-10 CN1C=C(C2=C(C3=C4CC(CN)CCN4C4=CC=CC=C34)C(=O)NC2=O)C2=CC=CC=C12ABC294640, also known as Opaganib, CAS No. 915385 81 8, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase 2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro apoptotic amino alcohol sphingosine to sphingosine 1 phosphate (S1P), the lipid mediator that is pro survival and critical for
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