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is non-toxic in SCID mice
18(5):415-420
and is selectively toxic for certain NSCLC cell lines
It inhibited the activity of human PRC2-containing wild-type EZH2 with an inhibition constant (Ki) value of 2
terminal half-life (2
LDN-214117 - CAS# 1627503-67-6 60245 is non-toxic in SCID miceLDN 214117, CAS No. 1627503 67 6, is a selective and potent ALK2 inhibitor. LDN 214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN 214117 shows a high degree of selectivity for ALK2 and low
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