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Structural studies revealed that the tert-butyl amine of UNC2170 anchors the compound in the methyl-lysine (Kme) binding pocket of 53BP1
Cucurbitacin I induces a concentration-dependent decrease in Stat3 expression whereas P-Stat3 is undetectable
Due to BI-3406 blocking the negative feedback relief induced by MAPK inhibition
Formula: C29H41F2N5O
InChi: InChI=1S/C10H18O/c1-5-10(4
Phthalimide-PEG4-PDM-OTBS CT007093 Structural studies revealed that thePhthalimide PEG4 PDM OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide PEG4 PDM OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin proteasome system to selectively degrade target proteins. Product information Molecular Weight: 536. 73
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