Pay in 4 interest-free payments of $30.00 Learn more
Ships within 48 hours · Estimated delivery Aug 17 - Aug 22
7-Dimethoxy-N-phenylquinazolin-4-amine
13a-secoberbin-13a-one
Optimizing management of ruxolitinib in patients with myelofibrosis: the need for individualized dosing
5 of vehicle group)
PubMed PMID: 28742863
GW791343 dihydrochloride 022 7-Dimethoxy-N-phenylquinazolin-4-amineGW791343 dihydrochloride is a P2X7 allosteric modulator; exhibits species specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6. 9 7. 2). IC50 value: 7 (pIC50) Target: P2X7 in vitro: In cells expressing human P2X7 receptors, GW 791343 inhibits agonist stimulated ethidium accumulation in both sucrose and NaCl buffer. In NaCl buffer, GW 791343 reduces the maximal response to both ATP and BzATP, but there is little effect