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10 nM and 36 nM
InChiKey: TYCGNZLSLVRAAR-MCDZGGTQSA-N
cyclin D1 protein expression
1'-pyrrolidin]-8-ylium chloride
ABT-767 selectively binds to PARP 1 and 2
SN-38 Size:Solid 2 mg 10 nM and 36 nMSN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be
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