Wf-516 6390 CZC-8004 (CZC-00008004) is a pan-kinase

CZC-8004 (CZC-00008004) is a pan-kinase inhibitor that binds a range of tyrosine kinases including ABL kinase

CAS Number: 28342-31-6

InChi: InChI=1S/C64H91N19O22/c1-31(2)52(68)62(103)81-44(30-88)57(98)74-37(21-48(66)90)55(96)78-41(27-85)56(97)73-36(20-47(65)89)54(95)76-39(19-33-22-69-35-13-7-6-12-34(33)35)64(105)83-17-9-15-46(83)61(102)79-42(28-86)58(99)75-38(18-32-10-4-3-5-11-32)63(104)82-16-8-14-45(82)60(101)80-43(29-87)59(100)77-40(26-84)53(94)72-25-51(93)71-24-50(92)70-23-49(67)91/h3-7

Chemical Name: 6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine

with IC50s of 1-2 nM against both isoforms

Wf-516 6390 CZC-8004 (CZC-00008004) is a pan-kinaseWf 516 is an inhibitor of 5 HT reuptake, and an antagonist of 5 HT1A and 5 HT2A receptors, with Ki of 5 nM and 40 nM for 5 HT1A receptor and 5 HT2A receptor in humans, respectively, and has potent antidepressant activity. Product information CAS Number: 310392 94 0 Molecular Weight: 502. 39 Formula: C25H25Cl2N3O4 Chemical Name: (2S) 1 [4 (3,4 dichlorophenyl)piperidin 1 yl] 3 {[2 (5 methyl 1,3,4 oxadiazol 2 yl) 1 benzofuran 4 yl]oxy}propan 2 ol Smiles: